BL – TerpeneTargets

p-cymene

p-Cymene is anti-bacterial. Is it also inhibit mammalian mitochondria? Yes, it uncouples respiration of isolated micochondria.

The featured study came out of Brazil. Many of the plant species the authors cited as being good sources of (32%) as well as limonene (28%) and carvone (28%). [2] Hydro are natives of Brazil Dill is also a good source of α-phellandrene (32%) as well as limonene (28%) and carvone (28%). [2] Hydro distillationContinue reading “α-phellandrene”

Carvacrol and TRPM2

Introduction The TRPM2 structure comes from RCSB.org entry 6PUS. It features human TRPM2 bound to ADP-ribose, an NAD+ metabolite produced under oxidative stress and/or neuro degenerative conditions. The TRPV4 is from Xenopus. 6C8H The gadolinium inhibitor (arrow) is part of this structure. The TRPM2 mRNA and TRPV4 mRNA expression data are from Proteinatlas.org. The firstContinue reading “Carvacrol and TRPM2”

Nerol

This post explores the binding of nerol to the human olfactory receptor OR2w3 in airway smooth muscle and thyroid cancer cells.

Sabinene

Sabinene was shown to be an jactive ingredient in Chrysanthemum boreale Makino essential oil. This post proposes that rather than a simple scavenger of reactive oxygen species sabinene is acting on PPAR alpha.

Frenchol

Frenchol is a primary terpene of basil and closely related to borneol. This is a journey that took some strange twists. Two groups of scientists were looking for neurological disease treatments. The paradoxical thing is that neither of the frenchol/fenchone targets are expressed in the brain in large amounts. They are both expressed in theContinue reading “Frenchol”

Carvacrol oregano oil

This post examines a report that oregano oil is a good treatment for foot pain. Carvacrol is a major terpene in oregano oil. Does carvcrol control pain pathways?

Cedrene and cedrol

An olfactory receptor in fat cells? Olfactory Receptor Family 10 Subfamily J Member 5 (OR10J5) is a typically G protein coupled receptor that signals through Gas pathways. GeneCards.org has perhaps the best expression data for OR10J5, the human version of Mouse olfactory receptor 23 MOR23. Tissue expression in the feature image is Illumina mRNA sequencingContinue reading “Cedrene and cedrol”

Terpinene

This post examines some biological actions and possible targets of four of the major terpenes in tea tree oil.

Phytol

This post examines some biochemistry of phytol and why it might cause pulmonary injury when vaped.