One of the first reports of a α-humulene comes from a company called Xenova in Slough Berkshire, UK. [1] Like many, they were looking for GABAA receptor modulators. “Recall that GABAA “receptors” are also chloride channels that, when open, lead to hyperpolarization and inhibition of neurotransmitter release. Benzodiazepines a class of modulators that increase theContinue reading “Humulene”


Sesquiterpenes are terpenes with the formula C15H24, hence the prefix “sesqui” Latin for 15. The featured study came out of Wuertzburg, Germany. These German authors extracted terpenes from hops and chamomile. [1] The extracts were subjected to a process to simulate digestion in the human gastrointestinal tract. β-Caryophyllene became β-caryophyllenol. Unlike many Asian studies reviewedContinue reading “Guaiol”

caryophyllene oxide

Caryophyllene oxide is produced when β-Caryophyllene is exposed to oxygen. The two structures of caryophyllene oxide come from ChEBI and PubChem. Folk medicine inspiration from the Brazilian Rain Forest Baccharis uncinella ,used by the Laklaño Indians, caught the attention of  several groups in Brazil that included Laboratório de Etnofarmacologia. [1].  In their introduction the authorsContinue reading “caryophyllene oxide”