Which strains of cannabis that are a good source of α-pinene is difficult to determine. Of all of the terpenes in cannabis, the investigators at the John Hopkins University Behavioral Pharmacology Research Unit is only considering the entourage of α-pinene and THC in their observational clinical trial. This post will make a case for α-pineneContinue reading “alpha-pinene”
The purpose of this post is to explain some nuances of a publication suggesting that sesquiterpenes bind to the first transmembrane M1 domain of the α1 sub unit of GABAA.  The same group that provided the X-ray crystal structure for a neurosteroid binding site that Janzen et al used later published a paper showingContinue reading “GABAA and PIP2”
Caryophyllene oxide is produced when β-Caryophyllene is exposed to oxygen. The two structures of caryophyllene oxide come from ChEBI and PubChem. Folk medicine inspiration from the Brazilian Rain Forest Baccharis uncinella ,used by the Laklaño Indians, caught the attention of several groups in Brazil that included Laboratório de Etnofarmacologia. . In their introduction the authorsContinue reading “caryophyllene oxide”
The featured study comes primarily from the Korean Institute of Science and Technology. Woo et al tell us that 3-carene is a component of pine essential oil.  The American College of Healthcare Science lists 3-carene as a component of many pine family extracts that also includes products such as juniper berry essential oil. Askgrowers.comContinue reading “3-carene”
(+)borneol is the GABAA receptor with preference for the alpha 2 subunit. This has implications as a terpene entourage of THC and the negative effects of THC on memor.