This post makes the case that eucalyptol, aka 1,8-cineole, is an activator of TRPM8 and an inhibitor of the L-type voltage gated calcium channel found in smooth muscle.
p-Cymene is anti-bacterial. Is it also inhibit mammalian mitochondria? Yes, it uncouples respiration of isolated micochondria.
Introduction The TRPM2 structure comes from RCSB.org entry 6PUS. It features human TRPM2 bound to ADP-ribose, an NAD+ metabolite produced under oxidative stress and/or neuro degenerative conditions. The TRPV4 is from Xenopus. 6C8H The gadolinium inhibitor (arrow) is part of this structure. The TRPM2 mRNA and TRPV4 mRNA expression data are from Proteinatlas.org. The firstContinue reading “Carvacrol and TRPM2”
This post examines some biological actions and possible targets of four of the major terpenes in tea tree oil.