Carvacrol and TRPM2

Introduction The TRPM2 structure comes from RCSB.org entry 6PUS. It features human TRPM2 bound to ADP-ribose, an NAD+ metabolite produced under oxidative stress and/or neuro degenerative conditions. The TRPV4 is from Xenopus. 6C8H The gadolinium inhibitor (arrow) is part of this structure. The TRPM2 mRNA and TRPV4 mRNA expression data are from Proteinatlas.org. The firstContinue reading “Carvacrol and TRPM2”

Cedrene and cedrol

An olfactory receptor in fat cells? Olfactory Receptor Family 10 Subfamily J Member 5 (OR10J5) is a typically G protein coupled receptor that signals through Gas pathways. GeneCards.org has perhaps the best expression data for OR10J5, the human version of Mouse olfactory receptor 23 MOR23. Tissue expression in the feature image is Illumina mRNA sequencingContinue reading “Cedrene and cedrol”

Terpenes and cell membranes

Terpene and lipid interactions: Not uncharted territory Terpene interactions with phospholipids in cell membranes and how those phospholipids communicate with receptors in those membranes is a bit of an unknown. However…. We already know more than we may realize just from the history of terpene use as transdermal permeablity enhancers. Trans dermal delivery of drugsContinue reading “Terpenes and cell membranes”

Pulegol and Curcumol

Curcumol is isolated from roots of plants of the family Zingiberaceaegenus {1] Within that family is the G genus Curcumus. North Americans are familiar with this as the common turmeric. Wei and coworkers have published an excellent review on the potential of curcumol to treat various aspects of the cancer process. [1] Isopulegol is theContinue reading “Pulegol and Curcumol”