Turning TRPV1 off

How can something like capsaicin of chili pepper fame/infame hurt like bloody hell and then have analgesic properties? We have covered the TRP family of Ca2+ channels on a page on this site. Nature has given us a negative feedback mechanism byway of a small Ca2+ modulated protein that we call calmodulin, of CaM forContinue reading “Turning TRPV1 off”

Myrcene, Terpenes, and TrpV1

This study came out of the laboratory of experimental medicine in Honolulu Hawaii. As a general background it might be worth while to review Ca2+-calmodulin inhibition of this Ca2+ channel and and Trp family overview. This group selected myrcene and and a mixture of strain inspired terpenes. The latter was identified as dominant terpenes inContinue reading “Myrcene, Terpenes, and TrpV1”